| Barber Motorsports Park | Birmingham AL | Honda Indy Grand Prix of Alabama | Alex Palou (2021) | Road | 17 | 2.300 mi |
| Exhibition Place | Toronto CAN | Honda Indy Toronto | Simon Pagenaud (2019) | Street | 11 | 1.786 mi |
| Indianapolis Motor Speedway (RC) | Speedway IN | GMR Grand Prix & Big Machine Spiked Coolers Grand Prix | Rinus VeeKay & Will Power (2021) | Road | 14 | 2.439 mi |
| Indianapolis Motor Speedway (Oval) | Speedway IN | The Indianapolis 500 Mile Race | Helio Castroneves (2021) | Oval | 4 | 2.500 mi |
| Iowa Speedway | Newton IA | Hy-VeeDeals.com 250 & Hy-Vee Salute to Farmers 300 | Simon Pagenaud & Josef Newgarden (2020) | Oval | 4 | 0.875 mi |
| Mid-Ohio Sports Car Course | Lexington OH | Honda Indy 200 at Mid-Ohio | Josef Newgarden (2021) | Road | 13 | 2.258 mi |
| Portland International Raceway | Portland OR | Grand Prix of Portland | Alex Palou (2021) | Road | 12 | 1.964 mi |
| The Raceway at Belle Isle Park | Detroit MI | Chevrolet Detroit Grand Prix | Marcus Ericsson & Pato O'Ward (2021) | Street | 14 | 2.350 mi |
| Road America | Elkhart Lake WI | REV Group Grand Prix | Alex Palou (2021) | Road | 14 | 4.014 mi |
| Streets of Long Beach | Long Beach CA | Acura Grand Prix of Long Beach | Colton Herta (2021) | Street | 11 | 1.968 mi |
| Streets of Nashville | Nashville TN | Big Machine Music City Grand Prix | Marcus Ericsson (2021) | Street | 11 | 2.170 mi |
| Streets of St. Petersburg | St. Petersburg FL | Firestone Grand Prix of St. Petersburg | Colton Herta (2021) | Street | 14 | 1.800 mi |
| Texas Motor Speedway | Fort Worth TX | XPEL 375 | Scott Dixon & Pato O'Ward (2021) | Oval | 4 | 1.500 mi |
| WeatherTech Raceway Laguna Seca | Salinas CA | Firestone Grand Prix of Monterey | Colton Herta (2021) | Road | 11 | 2.258 mi |
| World Wide Technology Raceway at Gateway | Madison IL | Bommarito Automotive Group 500 | Josef Newgarden (2021) | Oval | 4 | 1.250 mi |
