| Car No. | Driver | Team | Engine | Rounds |
|---|---|---|---|---|
| 1 | Tony Kanaan | Chip Ganassi Racing | Honda | Indy 500 |
| 2 | Josef Newgarden | Team Penske | Chevy | Full Season |
| 3 | Scott McLaughlin | Team Penske | Chevy | Full Season |
| 4 | Dalton Kellett | AJ Foyt Racing | Chevy | Full Season |
| 5 | Pato O'Ward | Arrow McLaren SP | Chevy | Full Season |
| 6 | Juan Pablo Montoya | Arrow McLaren SP | Chevy | May IMS Races |
| 06 | Helio Castroneves | Meyer Shank Racing | Honda | Full Season |
| 7 | Felix Rosenqvist | Arrow McLaren SP | Chevy | Full Season |
| 8 | Marcus Ericsson | Chip Ganassi Racing | Honda | Full Season |
| 9 | Scott Dixon | Chip Ganassi Racing | Honda | Full Season |
| 10 | Alex Palou | Chip Ganassi Racing | Honda | Full Season |
| 11 | Tatiana Calderon | AJ Foyt Racing | Chevy | Road/Street |
| 11 | JR Hildebrand | AJ Foyt Racing | Chevy | Ovals |
| 12 | Will Power | Team Penske | Chevy | Full Season |
| 14 | Kyle Kirkwood | AJ Foyt Racing | Chevy | Full Season |
| 15 | Graham Rahal | Rahal Letterman Lanigan Racing | Honda | Full Season |
| 16 | Simona De Silvestro | Paretta Autosport | Chevy | RA/MO/NAS |
| 18 | David Malukas | Dale Coyne Racing/HMD Motorsports | Honda | Full Season |
| 20 | Conor Daly | Ed Carpenter Racing | Chevy | Full Season |
| 21 | Rinus VeeKay | Ed Carpenter Racing | Chevy | Full Season |
| 23 | Santino Ferrucci | Dreyer & Reinbold Racing | Chevy | Indy 500 |
| 24 | Sage Karam | Dreyer & Reinbold Racing | Chevy | Indy 500 |
| 25 | Stefan Wilson | DragonSpeed LLC/Cusick Motorsports | Chevy | Indy 500 |
| 26 | Colton Herta | Andretti Autosport | Honda | Full Season |
| 27 | Alexander Rossi | Andretti Autosport | Honda | Full Season |
| 28 | Romain Grosjean | Andretti Autosport | Honda | Full Season |
| 29 | Devlin DeFrancesco | Andretti Steinbrenner Autosport | Honda | Full Season |
| 30 | Christian Lundgaard | Rahal Letterman Lanigan Racing | Honda | Full Season |
| 33 | Ed Carpenter | Ed Carpenter Racing | Chevy | Ovals |
| 45 | Santino Ferrucci | Rahal Letterman Lanigan Racing | Honda | Texas (Injury Sub) |
| 45 | Jack Harvey | Rahal Letterman Lanigan Racing | Honda | Full Season |
| 48 | Jimmie Johnson | Chip Ganassi Racing | Honda | Full Season |
| 51 | Takuma Sato | Dale Coyne Racing/Rick Ware Racing | Honda | Full Season |
| 60 | Simon Pagenaud | Meyer Shank Racing | Honda | Full Season |
| 77 | Callum Ilott | Juncos Hollinger Racing | Chevy | Full Season |
| 98 | Marco Andretti | Andretti Autosport | Honda | Indy 500 |
2022 INDY LIGHTS PRESENTED BY COOPER TIRES
| Car No. | Driver | Team | Rounds |
|---|---|---|---|
| 2 | Sting Ray Robb | Andretti Autosport | Full Season |
| 7 | Christian Bogle | HMD Motorsports/Dale Coyne Racing | Full Season |
| 11 | Antonio Serravalle | Abel Motorsports | Rounds 1&2 |
| 11 | Antonio Serravalle | HMD Motorsports/Dale Coyne Racing | Rounds 3&4 |
| 12 | James Roe | TJ Speed Motorsports | Full Season |
| 21 | Kyffin Simpson | TJ Speed Motorsports | Full Season |
| 24 | Benjamin Pedersen | Global Racing Group w/HMD Motorsports | Full Season |
| 26 | Linus Lundqvist | HMD Motorsports/Dale Coyne Racing | Full Season |
| 27 | Hunter McElrea | Andretti Autosport | Full Season |
| 28 | Christian Rasmussen | Andretti Autosport | Full Season |
| 51 | Jacob Abel | Abel Motorsports | Full Season |
| 59 | Manuel Sulaiman | HMD Motorsports/Dale Coyne Racing | Rounds 1&2 |
| 61 | Ryan Phinny | Abel Motorsports | Rounds 3&4 |
| 68 | Danial Frost | HMD Motorsports/Dale Coyne Racing | Full Season |
| 83 | Matthew Brabham | Andretti Autosport | Full Season |
| 99 | Ernie Francis Jr. | Force Indy | Full Season |
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